Category Archives: Metabolism and Metabolic Disease

Mediterranean Diet Associated with Decreased Risk of Metabolic Syndrome

The Mediterranean diet has been shown to bestow countless health benefits to those who consume it, including cardiovascular benefits, mental health benefits, and metabolic health benefits. Metabolic

Photo by Flickr user  Mike Denver (http://www.flickr.com/photos/nokolor/268292175)
Photo by Flickr user Mike Denver (http://www.flickr.com/photos/nokolor/268292175)

syndrome is of particular interest to researchers, as there have been significant increases in the various components of the condition (high blood pressure, high sugar levels, excess body weight, and abnormal cholesterol levels) in the recent years which is very likely to be related to dietary changes across all cultures.

A new study in press in the journal Metabolism aimed to examine the relationship between adherence to the Mediterranean diet and metabolic syndrome in Polish adults.

8821 Polish adults (aged 45-69 years) participated in this study. Dietary information was collected via self-reported questionnaire and adherence to the Mediterranean diet was scored using the MedTypeDiet Score system.

Height, weight, waist circumference, and blood pressure measurements were taken for each participant during a physical examination.

Other socio-demographic and lifestyle information was also collected.

Important Findings:

  • Adherence to the Mediterranean diet was the same between men and women.
  • MetTypeDiet scores were significantly (and negatively) associated with waist circumference, systolic blood pressure, and triglyceride levels.
  • Those with the highest adherence to the Mediterranean diet were least likely to have metabolic syndrome, obesity, high triglyceride levels, and hypertension.
  • Moderate wine consumption, low dairy intake, and a high unsaturated/saturated fatty acid ratio were negatively associated with metabolic syndrome.

The results of this study add to the mounting evidence that the Mediterranean diet is beneficial for lowering the risk of metabolic

Photo by Flickr user  waferboard (http://www.flickr.com/photos/waferboard/3273636749)
Photo by Flickr user waferboard (http://www.flickr.com/photos/waferboard/3273636749)

disease. Specifically, this study found that those with the high adherence to the Mediterranean diet were less likely to have metabolic syndrome, obesity, high triglyceride levels, and hypertension. Looking at individual dietary components, moderate wine consumption, low dairy intake and a higher ratio of unsaturated to saturated fatty acids resulted in a significantly lower risk of developing metabolic syndrome in Polish adults.

Source:

Grosso, G., Stepaniak, U., Micek, A., Topor-Mądry, R., Stefler, D., Szafraniec, K., Bobak, M., and Pająk, A. 2015. A Mediterranean-type diet is associated with better metabolic profile in urban Polish adults: Results from the HAPIEE study. Metabolism http://dx.doi.org/10.1016/j.metabol.2015.02.007

Simple Dietary Changes (ex. Increasing Fiber) May Be Just As Effective in Losing Weight Than Complicated Changes

Most of the studies on diet effectiveness one reads are focused on the more broad aspect of the diet. Specifically, there are many studies out there on the Mediterranean Diet, the Western Diet, the Paleo Diet, et cetera, however, what is less often studied is specific

Photo by Flickr user  Scott Teresi (http://www.flickr.com/photos/scott-teresi/4199022650)
Photo by Flickr user Scott Teresi (http://www.flickr.com/photos/scott-teresi/4199022650)

aspects within an individual diet, and how that specific aspect may or may not affect the health of the consumer.

A new study published in the journal Annals of Internal Medicine aimed to assess a diet based on the complex recommendations by the American Heart Association (AHA) compared with a more simple diet focused on high-fiber foods on adults with metabolic syndrome.

240 adults in the Worcester, MA area with metabolic syndrome were recruited for this study. Participants had BMIs between 30 and 40 kg/m2 and were between the ages of 21 and 70. Participants were mainly women, white, and well-educated.

Participants were randomly assigned a high-fiber diet or a diet based on AHA recommendations. Caloric intake for meals was determined to be appropriate for weight loss for each participant.

Weight and height was measured at the beginning of the study, and then at 3, 6, and 12 months post diet intervention.

Other information collected at each visit included: use of medications, use of dietary supplements, adherence to the study diets, fasting glucose levels, fasting plasma insulin levels, hemoglobin A1c, lipid profile, high-sensitivity C-reactive protein levels, interleukin-6 levels, tumor necrosis factor-α receptor 2 levels, and blood pressure.

Important Findings:

  • After 12 months, average weight loss for the high-fiber group was 2.1kg, while average weight loss for the AHA group was 2.7kg. These differences were not found to be significant.
  • 8 participants developed diabetes during the study (7 in the high-fiber group and 1 in the AHA group).
  • Reduction of caloric intake was greater in the AHA group than the high-fiber group.
  • Blood pressure and all metabolic measurements were similar between the two groups throughout the study, with both groups showing improvements.

The results of this study suggest that following a complex diet based on AHA recommendations is statistically similar to a more simple diet of just increasing the amount of fiber consumed. Technically, the amount of weight lost following the AHA diet was greater than the high-fiber diet, however, the loss was not statistically significant.

It is important to note that the number of calories consumed in the

Photo by Flickr user  mooglet (http://www.flickr.com/photos/mooglet/4663090967)
Photo by Flickr user mooglet (http://www.flickr.com/photos/mooglet/4663090967)

high-fiber group was higher, so it would make sense that the participants in that group would not lose as much weight. Keeping caloric intake constant between the two groups may have provided a more accurate comparison, but that was not done in this study.

Another caveat to this study is that the participant pool was mostly white women who are well-educated, making generalizations to other groups difficult (if not impossible).

In the end, the authors concluded that the results of this study suggest that a simplified dietary approach (such as increasing the fiber in one’s diet) may be just as beneficial as a more complicated diet regime, making weight loss and improvements in metabolic measurements more accessible and easier to follow for the general population.

Source:

Yunsheng, M., Olendzki, B.C., Wang, J., Persuitte, G.M., Li, W., Fang, H., Merriam, P.A., Wedick, N.M., Ockene, I.S., Culver, A.L., Schneider, K.L., Olendzki, G., Carmody, J., Ge, T., Zhang, Z., and Pagoto, S.L. 2015. Single-Component Versus Multicomponent Dietary Goals for the Metabolic Syndrome. Annals of Internal Medicine 162(4): 249-259.

Adherence to the Mediterranean Diet Associated with Lower Risk of Mortality and Death in Diabetes Patients

We’ve seen over and over again that the Mediterranean diet is associated with improved health over many systems, including the cardiovascular system, nervous system, and digestive system (just to name a few). Specifically here on this blog, we’ve seen studies showing that the Mediterranean diet is beneficial for reducing the

Photo by Flickr user  Oskar Annermarken (https://www.flickr.com/photos/oskarannermarken/6347508912)
Photo by Flickr user Oskar Annermarken (https://www.flickr.com/photos/oskarannermarken/6347508912)

risk of depression in people with diabetes, and adherence to the Mediterranean diet results in a 23% reduced risk in developing Type 2 diabetes.

A new study published in the European Journal of Preventive Cardiology aimed to take the research on the Mediterranean diet and diabetes a step further, and examined the relationship between adherence to the Mediterranean diet and mortality in people with diabetes.

1995 Italian adults with diabetes participated in this study. Food consumption habit information was collected by using self-reported questionnaires, after which results were given Greek Mediterranean Diet scores. Participants were followed for a total of 4 years.

Important Findings:

  • After 4 years, 109 patients had died (51 of them due to cardiovascular factors).
  • A 2 point increased in the Greek Mediterranean Diet Score was associated with an average 37% decrease in overall mortality in patients with diabetes.
  • A similar association was found when only those with cardiovascular mortality were the focus of analysis.
  • Adherence to a Mediterranean-style diet reduced the risk of death in diabetes patients.
  • The individual factors in the Mediterranean diet that contributed to this decreased risk of death and overall mortality in diabetes patients were:
    • Moderate alcohol consumption.
    • High consumption of cereals.
    • High consumption of vegetables.
    • Reduced consumption of meat and dairy products.

Overall, the results of this study suggest that for those people with

Photo by Flickr user  Kai Hendry (https://www.flickr.com/photos/hendry/2848365145)
Photo by Flickr user Kai Hendry (https://www.flickr.com/photos/hendry/2848365145)

diabetes, adherence to a Mediterranean-style diet reduces the risk of mortality and death. Specifically, moderate consumption of alcohol, as well as high consumption of cereal and vegetables and low consumption of meat and dairy products were all associated with this reduced risk of mortality and death in diabetes patients.

Source:

Bonaccio, M., Di Castelnuovo, A., Costanzo, S., Persichillo, M., De Curtis, A., Donati, M.B., de Gaetano, G., and Iacoviello, L. 2015. Adherence to the traditional Mediterranean diet and mortality in subjects with diabetes. Prospective results from the MOLI-SANI study. European Journal of Preventive Cardiology DOI: 10.1177/2047487315569409

The Mediterranean Diet Supplemented with Co-Enzyme Q10 Beneficial for Healthy Aging

Healthy aging is a concern of almost everyone, considering barring any unforeseen circumstances, we all grow older. Metabolism is one focus of healthy aging researchers, with variations in metabolism

Photo by Flickr user  Vinoth Chandar (http://www.flickr.com/photos/vinothchandar/8530944828)
Photo by Flickr user Vinoth Chandar (http://www.flickr.com/photos/vinothchandar/8530944828)

resulting in various ailments among the elderly. Additionally, outside factors that can influence metabolism, like diet and lifestyle choices, are of interest to researchers, as changes in these habits could lead to improved aging and reduced risk of disease and injury in the elderly.

A new study in the Journals of Gerontology: Medical Sciences looked at the effect of diet on the metabolic profile of elderly, by comparing the Mediterranean diet, the Mediterranean diet supplemented with Co-enzyme Q10, the Western diet rich in saturated fat, and a low-fat/high-carb diet rich in n-3 polyunsaturated fat.

This study followed 10 participants, with each participant consuming each of the four diets for a four week period each (16 weeks total).

Metabolic profile of urine of each participant was measured at the start of each diet, and again after a 12 hour fast at the completion of each diet.

Important Findings:

  • Comparing the Mediterranean & CO-Q (Med&CO-Q) diet with the Western/Saturated fat diet, women consuming the saturated fat diet had higher levels of phenylacteylglycine in their urine than those women consuming the Med&CO-Q diet.
  • The Med&CO-Q diet was positively associated with B-carotene plasma levels.
  • The Med&CO-Q diet was negatively associated with Nrf2, thioredoxin, superoxide dismutase 1, and the gp91phox subunit of NADPH oxidase gene expression.
  • The Western/Saturated fat diet was positively associated with isoprostane levels in urine.
  • The Western/Saturated fat diet was negatively associated with CO-Q plasma levels.

These results suggest that the Mediterranean Diet supplemented with Co-enzyme Q10 may be beneficial for healthy aging in elderly. The specific metabolic findings mentioned above indicate that the

Photo by Flickr user Moyan Brenn (http://www.flickr.com/photos/aigle_dore/5238549826)
Photo by Flickr user Moyan Brenn (http://www.flickr.com/photos/aigle_dore/5238549826)

Mediterranean Diet supplemented with Co-enzyme Q10 could reduce the risk of disease caused by chronic oxidative stress, cardiovascular diseases, and neurodegenerative diseases.

It is important to note the sample size in this study was very small (only 10 individuals), so more research is required to further support or refute these claims.

Source:

González-Guardia, L., Yubero-Serrano, E.M., Delgado-Lista, J., Perez-Martinez, P., Garcia-Rios, A., Marin, C., Camargo, A., Delgado-Casado, N., Roche, H.M., Perez-Jimenez, F., Brennan, L., and López-Miranda, J. 2015. Effects of the Mediterranean Diet Supplemented with Coenzyme Q10 on Metabolomic Profiles in Elderly Men and Women. Journals of Gerontology: Medical Sciences 70(1): 78-84.

Mediterranean Diet May Significantly Reduce Fatty Liver Disease Risk

Fatty liver disease is a metabolic condition that has been liked to type 2 diabetes as well as cardiovascular diseases. Specifically, fatty

Photo courtesy pixabay.com
Photo courtesy pixabay.com

liver disease is a known risk factor for these diseases, making care and prevention of the disease of utmost important in a world where type 2 diabetes and cardiovascular disease are all too prevalent in society.

A healthy diet, like a Mediterranean-style diet, has been often cited as a way to reduce the risk of fatty liver disease and associated diseases such as type 2 diabetes and cardiovascular disease.

A new study published in the journal Current Opinion in Lipidology reviewed published research on the effects of diet on the risk of fatty liver disease from March 2013 through August 2014. A total of 5 peer-reviewed studies were published during this time period and used for analysis.

Important Findings:

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